Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type	Study_count
Total_Studies	1302
interventional	1145
Observational	141
Registry	16

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	591
Biological	109
Biological\|Drug	79
Drug\|Other	51
Biological\|Drug\|Other	47
Drug\|Procedure	29
Biological\|Drug\|Procedure\|Radiation	22
Biological\|Drug\|Other\|Procedure\|Radiation	17
Drug\|Radiation	17
Drug\|Procedure\|Radiation	16
Biological\|Other	13
Drug\|Other\|Procedure\|Radiation	13
Drug\|placebo	12
Other	12
Procedure	12
Behavioral	11
Biological\|Drug\|Other\|Procedure	8
Biological\|Drug\|Radiation	7
Drug\|Genetic	7
Dietary Supplement	6
Drug\|Other\|Radiation	6
Biological\|Drug\|Procedure	5
Combination Product	5
Device	5
Drug\|Genetic\|Other	3
Drug\|Other\|Procedure	3
Biological\|Device\|Drug	2
Biological\|Drug\|Genetic\|Other\|Procedure	2
Biological\|Procedure	2
Device\|Other	2
Dietary Supplement\|Other	2
Dietary Supplement\|placebo	2
Other\|Procedure	2
Behavioral\|Drug\|Other\|Procedure	1
Biological\|Device	1
Biological\|Device\|Drug\|Other\|Procedure	1
Biological\|Device\|Drug\|Procedure\|Radiation	1
Biological\|Device\|Drug\|Radiation	1
Biological\|Drug\|Genetic\|Other	1
Biological\|Drug\|Other\|Radiation	1
Biological\|Genetic\|Other	1
Biological\|Genetic\|Other\|Procedure	1
Biological\|Other\|Procedure	1
Biological\|placebo	1
Device\|Drug	1
Device\|Drug\|Other	1
Device\|Drug\|Other\|Procedure\|Radiation	1
Device\|Drug\|Procedure	1
Device\|Drug\|Procedure\|Radiation	1
Diagnostic Test\|Drug	1
Diagnostic Test\|Drug\|Genetic\|Procedure\|Radiation	1
Dietary Supplement\|Drug	1
Dietary Supplement\|Drug\|Other	1
Drug\|Genetic\|Procedure\|Radiation	1
Drug\|Other\|placebo\|Procedure	1
Drug\|placebo\|Procedure	1
Genetic	1
Genetic\|Other	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country	Study_Count
United States	627
China	52
Germany	36
France	26
Italy	23
Spain	21
NA	20
Japan	18
United States\|Canada	17
United Kingdom	16
Canada	11
Korea, Republic of	10
United States\|Australia\|Canada	8
Austria	7
United States\|Australia	7
Denmark	5
Mexico	5
Sweden	4
United States\|Australia\|Canada\|Puerto Rico	4
United States\|Germany\|Italy	4
United States\|Italy	4
Austria\|Germany	3
Denmark\|Finland\|Iceland\|Norway\|Sweden	3
Israel	3
Russian Federation	3
Turkey	3
United States\|Australia\|Canada\|Netherlands\|Puerto Rico\|Switzerland	3
United States\|Australia\|Canada\|New Zealand\|Puerto Rico	3
United States\|Australia\|Canada\|New Zealand\|Switzerland	3
United States\|France\|Germany\|Italy\|United Kingdom	3
United States\|Germany	3
United States\|United Kingdom	3
Austria\|France\|Germany	2
Germany\|Austria	2
Hong Kong	2
Lithuania	2
Spain\|United States\|Argentina\|Australia\|Austria\|Brazil\|Bulgaria\|Canada\|Croatia\|Czechia\|Denmark\|Egypt\|Estonia\|France\|Germany\|Hong Kong\|Italy\|Mexico\|Netherlands\|New Zealand\|Romania\|Russian Federation\|Slovakia\|Switzerland\|Thailand\|United Kingdom	2
Switzerland	2
United States\|Australia\|Austria\|Belgium\|France\|Germany\|Hungary\|Italy\|New Zealand\|Spain\|United Kingdom	2
United States\|Australia\|Belgium\|Canada\|China\|Czechia\|Ireland\|Israel\|Italy\|New Zealand\|Poland\|Russian Federation\|Spain\|Turkey\|Ukraine\|United Kingdom	2
United States\|Australia\|Canada\|Ireland\|New Zealand\|Puerto Rico\|Switzerland	2
United States\|Australia\|Canada\|New Zealand	2
United States\|Australia\|France\|Poland	2
United States\|Canada\|France\|Netherlands	2
United States\|Canada\|Puerto Rico	2
United States\|Denmark\|Germany	2
United States\|France\|Germany	2
United States\|Puerto Rico\|South Africa	2
Argentina\|Australia\|Austria\|Belarus\|Belgium\|Canada\|Chile\|Croatia\|Czechia\|Denmark\|Finland\|France\|Germany\|Greece\|Hungary\|Israel\|Italy\|Malaysia\|Mexico\|Netherlands\|New Zealand\|Norway\|Poland\|Romania\|Saudi Arabia\|Slovakia\|Slovenia\|Spain\|Sweden\|Switzerland\|Turkey	1
Argentina\|Australia\|Brazil\|Canada\|Chile\|Croatia\|Czechia\|France\|Germany\|Greece\|Italy\|Mexico\|New Zealand\|Poland\|Portugal\|Russian Federation\|Slovakia\|Spain\|Turkey	1
Argentina\|Australia\|Bulgaria\|Hong Kong\|Hungary\|Mexico\|New Zealand\|Poland\|Russian Federation\|Taiwan	1
Argentina\|Austria\|Belgium\|Chile\|Czech Republic\|Germany\|Hungary\|Italy	1
Argentina\|Belgium\|Bosnia and Herzegovina\|Brazil\|Canada\|Egypt\|Estonia\|Finland\|France\|Germany\|Greece\|Ireland\|Israel\|Italy\|Korea, Republic of\|Latvia\|Lithuania\|Mexico\|North Macedonia\|Poland\|Portugal\|Romania\|Russian Federation\|Serbia\|Slovakia\|Slovenia\|Spain\|Sweden\|Switzerland\|Thailand\|Turkey	1
Argentina\|Belgium\|Canada\|Denmark\|Finland\|France\|Italy\|Netherlands\|Norway\|Sweden	1
Argentina\|Croatia\|Greece\|Ireland\|Italy\|New Zealand\|Russian Federation\|United Kingdom	1
Argentina\|Venezuela	1
Armenia\|Belarus\|Kyrgyzstan\|Russian Federation\|Uzbekistan	1
Australia\|Austria\|Belgium\|Czech Republic\|Denmark\|France\|Germany\|Israel\|Italy\|New Zealand\|Spain	1
Australia\|Austria\|Czechia\|Germany\|Israel\|Italy\|Slovakia\|Switzerland	1
Australia\|Austria\|Czechia\|Germany\|Israel\|Italy\|Switzerland	1
Australia\|Belgium\|France\|Germany\|Italy\|Korea, Republic of\|Netherlands\|Singapore\|Spain\|Sweden\|United Kingdom	1
Australia\|China\|New Zealand\|Taiwan	1
Australia\|France\|Germany\|Hungary\|Korea, Republic of\|Poland\|Singapore\|United Kingdom	1
Australia\|United Kingdom	1
Austria\|Belgium\|Bulgaria\|Czechia\|France\|Germany\|Hungary\|Ireland\|Israel\|Italy\|Poland\|Russian Federation\|Singapore\|Slovakia\|Sweden\|Ukraine\|United Kingdom	1
Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Japan\|Norway\|Spain	1
Austria\|Belgium\|France\|Germany\|Italy\|Netherlands\|Poland\|Romania\|Russian Federation\|Spain\|United Kingdom	1
Austria\|Belgium\|France\|Italy	1
Austria\|Brazil\|United States\|Argentina\|Australia\|Bulgaria\|Canada\|Croatia\|Czechia\|Denmark\|Egypt\|Estonia\|France\|Germany\|Hong Kong\|Italy\|Mexico\|Netherlands\|New Zealand\|Romania\|Russian Federation\|Slovakia\|Spain\|Switzerland\|Thailand\|United Kingdom	1
Austria\|Czechia\|Slovakia	1
Austria\|Finland\|Germany\|Russian Federation	1
Austria\|France\|Germany\|Italy\|Netherlands\|United Kingdom	1
Austria\|Germany\|Switzerland	1
Bangladesh	1
Belarus\|Poland	1
Belarus\|Russian Federation\|Uzbekistan	1
Belgium	1
Belgium\|Croatia\|Czech Republic\|France\|Germany\|Italy\|Netherlands\|Portugal\|Slovakia\|Turkey	1
Belgium\|Denmark\|Estonia\|Finland\|Germany\|Iceland\|Ireland\|Lithuania\|Netherlands\|Norway\|Portugal\|Sweden\|United Kingdom	1
Belgium\|Denmark\|Netherlands	1
Belgium\|France	1
Belgium\|France\|Germany	1
Belgium\|France\|Germany\|Italy	1
Belgium\|France\|United States\|Israel\|Spain\|United Kingdom	1
Belgium\|Netherlands	1
Brazil	1
Bulgaria\|Georgia\|Poland	1
Canada\|France	1
Canada\|Germany	1
Canada\|Russian Federation\|Spain	1
Canada\|United States\|Australia\|New Zealand\|Switzerland	1
China\|Malaysia\|Australia\|Taiwan	1
China\|Philippines\|Taiwan\|Thailand\|Vietnam	1
Czech Republic	1
Denmark\|Estonia\|Finland\|Lithuania\|Norway\|Sweden	1
Denmark\|Sweden	1
Egypt	1
France\|Germany\|Spain	1
France\|United Kingdom	1
Germany\|Austria\|Belgium\|Denmark\|Finland\|Ireland\|Israel\|Netherlands\|Sweden\|Switzerland	1
Germany\|Netherlands	1
Germany\|Netherlands\|United Kingdom	1
Germany\|United States\|Australia\|Austria\|Belgium\|Canada\|Denmark\|Finland\|France\|Hong Kong\|Italy\|Korea, Republic of\|Netherlands\|New Zealand\|Norway\|Poland\|Singapore\|Spain\|Sweden\|Switzerland\|Taiwan\|United Kingdom	1
Greece	1
Hong Kong\|Japan\|Malaysia\|Singapore\|Taiwan	1
India	1
Iran, Islamic Republic of	1
Japan\|Korea, Republic of	1
Malaysia	1
Netherlands	1
Netherlands\|United Kingdom	1
Poland\|Spain	1
Poland\|United Kingdom	1
Spain\|Finland\|France\|Portugal\|Sweden\|Tunisia\|Turkey\|United Kingdom	1
Spain\|United States\|Australia\|Austria\|Belgium\|Canada\|Colombia\|Czechia\|Denmark\|France\|Germany\|Hungary\|Ireland\|Israel\|Italy\|Mexico\|Netherlands\|New Zealand\|Poland\|Portugal\|Romania\|Russian Federation\|South Africa\|Sweden\|United Kingdom	1
Spain\|United States\|Australia\|Belgium\|Denmark\|France\|Germany\|Hungary\|Israel\|Italy\|Netherlands\|New Zealand\|Poland\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belarus\|Brazil\|Bulgaria\|Canada\|Finland\|France\|Greece\|Italy\|Korea, Republic of\|Poland\|Russian Federation\|Spain\|Taiwan\|Turkey	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|Denmark\|Finland\|France\|Germany\|Israel\|Italy\|Korea, Republic of\|Netherlands\|Norway\|Peru\|Sweden\|Switzerland\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Brazil\|Bulgaria\|Canada\|Croatia\|Denmark\|Estonia\|France\|Germany\|Italy\|Mexico\|New Zealand\|Poland\|Romania\|Russian Federation\|Spain\|Switzerland\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Brazil\|Bulgaria\|Canada\|Czechia\|Denmark\|France\|Germany\|Hungary\|Israel\|Italy\|Korea, Republic of\|Netherlands\|Poland\|Russian Federation\|Saudi Arabia\|Slovakia\|South Africa\|Spain\|Sweden\|Taiwan\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Canada\|China\|Colombia\|Czechia\|France\|Germany\|Greece\|Hungary\|Ireland\|Israel\|Italy\|Korea, Republic of\|Mexico\|Netherlands\|Poland\|Portugal\|Russian Federation\|Spain\|Sweden\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Brazil\|Canada	1
United States\|Argentina\|Australia\|Canada\|China\|Czechia\|Finland\|France\|Germany\|Hungary\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Poland\|Singapore\|Spain\|Sweden\|Taiwan\|United Kingdom	1
United States\|Argentina\|Belgium\|Brazil\|Canada\|Colombia\|Czechia\|France\|Germany\|Greece\|Israel\|Korea, Republic of\|Mexico\|Poland\|Portugal\|Russian Federation\|Spain\|Sweden\|Turkey\|Ukraine\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Croatia\|Czechia\|Denmark\|France\|Hungary\|Israel\|Italy\|Netherlands\|New Zealand\|Poland\|Portugal\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Bulgaria\|Canada\|Croatia\|Czechia\|France\|Germany\|Hong Kong\|Hungary\|Israel\|Italy\|Korea, Republic of\|New Zealand\|Poland\|Russian Federation\|Singapore\|Slovakia\|Spain\|Sweden\|Taiwan\|Ukraine\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|Czechia\|Denmark\|France\|Germany\|Hungary\|Italy\|Korea, Republic of\|Netherlands\|New Zealand\|Poland\|Russian Federation\|Spain\|Sweden\|Taiwan\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|Czechia\|France\|Israel\|Italy\|New Zealand\|Poland\|Russian Federation\|Spain\|Sweden\|Turkey\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Japan\|Norway\|Spain	1
United States\|Australia\|Austria\|Belgium\|Czechia\|France\|Italy\|New Zealand\|Poland\|Russian Federation\|Spain\|Sweden\|Taiwan\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|France\|Ireland\|Italy\|Poland\|Spain\|United Kingdom	1
United States\|Australia\|Austria\|Canada\|Denmark\|France\|Israel\|Italy\|Netherlands\|Spain\|Switzerland\|United Kingdom	1
United States\|Australia\|Belgium\|Brazil\|Canada\|Czechia\|Korea, Republic of\|Mexico\|New Zealand\|Poland\|Puerto Rico\|Russian Federation	1
United States\|Australia\|Belgium\|Canada\|Croatia\|Czechia\|France\|Greece\|Hungary\|Ireland\|Italy\|Poland\|Portugal\|Romania\|Russian Federation\|Spain\|Turkey\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Denmark\|France\|Hungary\|Italy\|Netherlands\|New Zealand\|Norway\|Poland\|Romania\|Russian Federation\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Germany\|New Zealand\|Sweden\|Turkey\|United Kingdom	1
United States\|Australia\|Belgium\|China\|Czechia\|France\|Germany\|Italy\|Netherlands\|New Zealand\|Poland\|Spain\|Sweden\|Turkey\|United Kingdom	1
United States\|Australia\|Belgium\|France\|Germany\|Italy\|Netherlands\|Puerto Rico\|United Kingdom	1
United States\|Australia\|Belgium\|Hungary\|India\|Poland\|Singapore\|Spain\|Taiwan\|Turkey	1
United States\|Australia\|Brazil\|Canada	1
United States\|Australia\|Brazil\|Canada\|Denmark\|Finland\|France\|Germany\|Italy\|Korea, Republic of\|Netherlands\|Norway\|Russian Federation\|Spain\|Sweden\|Taiwan\|United Kingdom	1
United States\|Australia\|Brazil\|Czech Republic\|France\|Israel\|Italy\|Poland\|Puerto Rico\|Russian Federation\|Ukraine\|United Kingdom	1
United States\|Australia\|Canada\|France\|Germany\|Korea, Republic of\|Spain\|United Kingdom	1
United States\|Australia\|Canada\|France\|Germany\|Poland\|United Kingdom	1
United States\|Australia\|Canada\|Italy\|Puerto Rico\|United Kingdom	1
United States\|Australia\|Canada\|Netherlands\|New Zealand\|Puerto Rico\|Switzerland	1
United States\|Australia\|Canada\|New Zealand\|Puerto Rico\|Saudi Arabia	1
United States\|Australia\|Canada\|Switzerland	1
United States\|Australia\|France\|Germany\|Israel\|Korea, Republic of\|Spain	1
United States\|Australia\|France\|Germany\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Singapore\|Spain	1
United States\|Australia\|France\|Italy\|Spain	1
United States\|Australia\|Germany\|United Kingdom	1
United States\|Australia\|Israel\|Poland\|Ukraine	1
United States\|Australia\|Italy\|New Zealand\|Spain	1
United States\|Australia\|New Zealand	1
United States\|Austria	1
United States\|Austria\|Belgium\|Canada\|Denmark\|Finland\|France\|Germany\|Greece\|Ireland\|Israel\|Italy\|Netherlands\|Norway\|Portugal\|Puerto Rico\|Spain\|Sweden\|Switzerland\|Turkey\|United Kingdom	1
United States\|Austria\|Belgium\|Czech Republic\|France\|Germany\|Ireland\|Italy\|Netherlands\|Sweden\|United Kingdom	1
United States\|Austria\|Bulgaria\|Canada\|Croatia\|France\|Germany\|Greece\|Italy\|Poland\|Portugal\|Romania\|Russian Federation\|Sweden\|Ukraine	1
United States\|Austria\|Canada\|France\|Germany\|Italy\|Netherlands	1
United States\|Austria\|Germany\|Italy\|Poland\|United Kingdom	1
United States\|Austria\|Germany\|Italy\|Spain	1
United States\|Austria\|Germany\|Poland\|Spain	1
United States\|Belgium\|Canada\|Czechia\|Denmark\|France\|Israel\|Netherlands\|Poland\|Russian Federation\|Spain\|Sweden\|Turkey\|United Kingdom	1
United States\|Belgium\|Canada\|Denmark\|Finland\|France\|Germany\|Italy\|Netherlands\|Norway\|Spain\|United Kingdom	1
United States\|Belgium\|Canada\|France\|Germany\|Israel\|Italy\|Poland	1
United States\|Belgium\|Czech Republic\|France\|Serbia\|United Kingdom	1
United States\|Belgium\|Czech Republic\|Greece\|Italy\|Poland\|Russian Federation\|Spain	1
United States\|Belgium\|France\|Germany\|Israel\|Italy\|Netherlands\|Spain\|Sweden\|United Kingdom	1
United States\|Belgium\|France\|Italy\|Netherlands\|Spain	1
United States\|Brazil\|Bulgaria\|Canada\|Germany\|Greece\|India\|Italy\|Mexico\|Netherlands\|Poland\|Romania\|Russian Federation\|Spain\|Taiwan\|Thailand\|Ukraine\|United Kingdom	1
United States\|Brazil\|France\|Italy\|Korea, Republic of\|Netherlands\|Russian Federation\|United Kingdom	1
United States\|Canada\|France\|Germany\|Italy\|Spain\|Sweden\|United Kingdom	1
United States\|Canada\|France\|Germany\|Netherlands	1
United States\|Canada\|Georgia\|Moldova, Republic of\|Poland\|Spain\|Ukraine	1
United States\|Canada\|Germany\|Israel\|United Kingdom	1
United States\|Canada\|Germany\|Italy\|Spain\|Sweden\|United Kingdom	1
United States\|Canada\|Israel\|Puerto Rico	1
United States\|Canada\|Netherlands\|Puerto Rico\|Switzerland	1
United States\|Canada\|Puerto Rico\|South Africa	1
United States\|Canada\|Puerto Rico\|Switzerland	1
United States\|Denmark	1
United States\|Denmark\|France\|United Kingdom	1
United States\|Denmark\|Italy	1
United States\|Egypt\|India	1
United States\|France	1
United States\|France\|Germany\|Italy\|Japan\|Netherlands\|United Kingdom	1
United States\|France\|Germany\|Italy\|Spain\|United Kingdom	1
United States\|France\|Germany\|Italy\|Switzerland\|United Kingdom	1
United States\|France\|Italy\|Spain	1
United States\|France\|Japan\|United Kingdom	1
United States\|France\|Spain\|United Kingdom	1
United States\|Germany\|Israel	1
United States\|Germany\|Italy\|Spain	1
United States\|Hungary\|Israel\|Italy\|Spain	1
United States\|Israel	1
United States\|Israel\|Italy\|Poland\|Russian Federation\|Spain\|United Kingdom	1
United States\|Italy\|United Kingdom	1
United States\|Japan	1
United States\|Poland	1
United States\|Puerto Rico	1
United States\|Sweden	1
United States\|Switzerland	1

Sites per Study

Site_count	Study_Count
1	535
2	84
3	49
4	34
5	32
6	35
7	16
8	12
9	13
10	17
11	20
12	15
13	11
14	9
15	9
16	9
17	6
18	9
19	5
20	4
21	4
22	13
23	6
24	6
25	7
26	3
27	4
28	6
29	1
30	4
31	3
32	2
33	9
34	8
35	5
36	3
38	2
39	2
41	1
42	2
43	2
44	2
46	3
48	3
50	4
51	3
52	2
53	1
54	2
55	1
56	1
57	1
58	4
60	1
63	1
64	1
66	1
67	1
69	2
70	1
71	3
72	1
75	2
76	2
78	1
79	1
80	1
81	2
84	1
85	1
86	1
87	2
88	2
91	3
92	1
94	1
97	1
101	3
102	1
103	1
106	2
107	1
108	2
111	1
113	2
115	1
117	2
119	1
122	1
123	2
128	1
130	1
134	1
135	2
139	1
145	1
150	2
153	1
157	1
160	3
161	1
162	1
164	1
165	1
170	1
171	1
173	2
174	1
186	1
188	1
196	1
198	1
199	1
210	1
212	1
215	1
218	1
224	1
225	1
239	1
241	1
244	1
262	3
299	1
364	1
551	1
743	1
796	1
835	1
954	1

Phase

Phase	Study_Count
Phase 2	463
Phase 1	271
Phase 1/Phase 2	162
Phase 3	131
N/A	61
Phase 4	31
Phase 2/Phase 3	16
Early Phase 1	10

Number of Arms

Number_of_Arms	Count_of_Studies
1	651
2	235
3	60
4	31
5	14
6	7
7	8
8	5
9	2
10	6
11	1
12	1
17	1
NA	123

Number of Updates

Count of Versions	Count of Studies
1	37
2	56
3	53
4	51
5	53
6	62
7	54
8	44
9	45
10	39
11	46
12	43
13	39
14	28
15	24
16	23
17	27
18	30
19	15
20	19
21	19
22	18
23	21
24	17
25	14
26	17
27	16
28	13
29	9
30	15
31	7
32	12
33	7
34	6
35	4
36	7
37	2
38	4
39	6
40	4
41	4
42	6
43	2
44	2
45	3
46	3
47	1
48	4
49	2
50	2
51	5
52	5
53	4
55	3
56	2
57	2
58	2
59	1
60	1
61	3
62	3
63	2
64	2
65	3
66	1
67	1
69	1
71	1
72	3
73	1
74	2
75	3
77	1
79	2
80	1
81	2
83	2
84	1
85	3
86	2
87	1
91	2
94	1
96	1
105	1
107	1
109	1
115	1
118	1
121	1
125	2
130	1
136	1
139	1
141	1
148	1
154	1
156	1
157	1
158	1
185	1
189	2
205	2
232	1
240	1
241	1
292	1
304	2
326	1
349	1
376	1
397	1
418	1
428	1
455	1
482	1
510	1
630	1
870	1
883	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	28763	1108	25.959386
Contacts/Locations	14605	1023	14.276637
Arms	2519	768	3.279948
Interventions	2519	768	3.279948
Eligibility	2311	754	3.064987
Recruitment Status	2264	1004	2.254980
Study Description	2212	674	3.281899
Study Design	2101	848	2.477594
Study Identification	1927	733	2.628922
Outcome Measures	1844	742	2.485175
Sponsor/Collaborators	1376	681	2.020558
Conditions	1252	493	2.539554
None (earliest Version on record)	1145	1145	1.000000
Oversight	1018	642	1.585670
References	711	317	2.242902
More Information	544	177	3.073446
Results	264	264	1.000000
IPDSharing	176	137	1.284671
Baseline Characteristics	105	77	1.363636
Results Submission Events	85	85	1.000000
Documents	70	65	1.076923
Reported Adverse Events	70	61	1.147541
Participant Flow	60	49	1.224490
2020 Outcome Measures	1	1	1.000000
Quality Control Review has not concludedReturned: March 18	1	1	1.000000

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	4.00	2.0000	2.00000	1.0000	2.00000	10.0000	40.0000	9.0000
1st Qu.	6.25	30.7500	16.00000	30.0000	30.00000	40.5000	211.0000	65.0000
Median	16.50	59.5000	29.00000	42.0000	50.00000	88.0000	400.0000	100.0000
Mean	46.90	191.6207	41.94052	68.6478	70.15367	194.5625	849.7984	277.4839
3rd Qu.	33.75	103.5000	48.00000	79.5000	86.00000	137.5000	775.0000	347.5000
Max.	312.00	4000.0000	746.00000	942.0000	470.00000	1000.0000	9350.0000	2600.0000

Trial Group Type

group_type	Group_Count
Experimental	1456
Active Comparator	188
NA	123
No Intervention	42
Other	42
Placebo Comparator	22
Sham Comparator	1

Intervention Model

intervention_model	Study_Count
Single Group Assignment	768
Parallel Assignment	278
NA	50
Sequential Assignment	28
Crossover Assignment	14
Factorial Assignment	7

Primary Purpose

primary_purpose	Study_Count
Treatment	1074
Supportive Care	35
Prevention	17
Basic Science	9
Other	4
NA	4
Diagnostic	1
Health Services Research	1

Observational Studies

Studies by Country

Country	Study_Count
United States	45
France	11
NA	9
Denmark	8
Italy	7
Korea, Republic of	5
Greece	4
Israel	4
Russian Federation	4
Canada	3
Spain	3
Argentina	2
India	2
Ireland\|United Kingdom	2
Mexico	2
Sweden	2
Austria\|Germany\|Italy	1
Austria\|Germany\|Switzerland	1
Belgium	1
Belgium\|France\|Portugal	1
China	1
Czech Republic\|France\|Germany\|Italy\|Poland\|Russian Federation\|Spain\|United Kingdom	1
Czechia	1
Denmark\|Finland\|Iceland\|Lithuania\|Norway\|Sweden	1
Denmark\|Finland\|Iceland\|Norway\|Sweden	1
Egypt	1
Finland	1
Germany	1
Guatemala	1
Hungary	1
Indonesia	1
Italy\|Switzerland	1
Japan	1
Serbia	1
Switzerland	1
United Kingdom	1
United States\|Australia\|Canada	1
United States\|Australia\|Canada\|Ireland\|New Zealand\|Puerto Rico\|Switzerland	1
United States\|Australia\|Canada\|New Zealand	1
United States\|Australia\|Canada\|New Zealand\|Puerto Rico\|Switzerland	1
United States\|Australia\|Canada\|Puerto Rico\|Switzerland	1
United States\|Canada	1
United States\|Czech Republic\|France\|Germany\|Italy\|Poland\|Spain\|United Kingdom	1
United States\|Netherlands	1

Sites per Study

Site_count	Study_Count
1	80
2	6
3	6
4	2
5	5
6	1
8	1
9	2
10	2
11	1
13	2
14	2
15	2
16	1
17	2
18	1
19	2
21	1
25	1
31	1
33	1
34	1
35	1
39	1
41	2
47	1
51	1
55	1
59	1
66	1
71	1
84	1
112	1
135	1
137	1
165	1
183	1
200	1
244	1

Number of Updates

Count of Versions	Count of Studies
1	14
2	19
3	17
4	12
5	12
6	6
7	4
8	2
9	7
10	6
11	4
13	2
14	4
15	2
17	2
20	1
22	1
23	1
25	1
27	2
30	1
45	1
47	1
66	1
71	1
73	1
78	2
83	1
84	1
118	1
122	1
124	1
126	1
164	1
185	1
239	1
297	1
341	1
364	1
391	1
460	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	4190	127	32.992126
Contacts/Locations	2406	102	23.588235
Study Description	199	50	3.980000
Recruitment Status	197	104	1.894231
Study Design	197	90	2.188889
None (earliest Version on record)	141	141	1.000000
Eligibility	132	64	2.062500
Outcome Measures	103	62	1.661290
Study Identification	101	62	1.629032
Groups	96	39	2.461539
Interventions	96	39	2.461539
Conditions	85	41	2.073171
Sponsor/Collaborators	81	62	1.306452
Oversight	69	50	1.380000
References	46	21	2.190476
IPDSharing	11	9	1.222222
Results	3	3	1.000000
Results Submission Events	3	3	1.000000
Documents	1	1	1.000000
More Information	1	1	1.000000

Enrollment Metrics

Measure	Observational
Min	1.0000
1st Qu	63.7500
Median	155.5000
Mean	724.6857
3rd Qu	438.5000
Max	17463.0000

Observation Model

observational_model	Study_Count
Cohort	80
Case-Only	26
Other	10
NA	8
Case-Control	7
Case Control	5
Family-Based	3
Case-Crossover	1
Defined Population, Natural History	1

Time Perspective

time_perspective	Study_Count
Prospective	82
Retrospective	36
Cross-Sectional	9
Other	8
NA	4
Cross-Sectional, Retrospective	1
Longitudinal, Prospective	1

Registries

Studies by Country

Country	Study_Count
United States	5
France	2
NA	2
China	1
Czechia	1
Germany	1
Indonesia	1
Italy	1
Sweden	1
Turkey	1

Sites per Study

Site_count	Study_Count
1	10
2	3
10	1
51	1
192	1

Number of Updates

Count of Versions	Count of Studies
1	5
2	1
3	2
4	2
5	2
6	1
11	1
13	1
23	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	68	11	6.181818
Contacts/Locations	27	8	3.375000
None (earliest Version on record)	16	16	1.000000
Study Design	11	7	1.571429
Recruitment Status	9	7	1.285714
References	6	1	6.000000
Eligibility	5	3	1.666667
Outcome Measures	5	2	2.500000
Study Identification	5	4	1.250000
Sponsor/Collaborators	4	3	1.333333
Study Description	4	3	1.333333
Conditions	3	2	1.500000
Groups	2	2	1.000000
Interventions	2	2	1.000000
Oversight	2	2	1.000000
IPDSharing	1	1	1.000000

Enrollment Metrics

Measure	Registries
Min	24.000
1st Qu	199.500
Median	510.500
Mean	2177.125
3rd Qu	2448.750
Max	10000.000

Registry Model

observational_model	Study_Count
Cohort	11
Other	4
Case-Only	1

Time Perspective

time_perspective	Study_Count
Prospective	12
Cross-Sectional	2
Other	2

Follow-up

target_duration	Study_Count
10 Years	5
2 Years	3
1 Year	2
1 Day	1
12 Months	1
15 Years	1
20 Years	1
3 Years	1
5 Years	1

intervention_type	Study_Count
Drug	591
Biological	109
Biological\|Drug	79
Drug\|Other	51
Biological\|Drug\|Other	47
Drug\|Procedure	29
Biological\|Drug\|Procedure\|Radiation	22
Biological\|Drug\|Other\|Procedure\|Radiation	17
Drug\|Radiation	17
Drug\|Procedure\|Radiation	16
Biological\|Other	13
Drug\|Other\|Procedure\|Radiation	13
Drug\|placebo	12
Other	12
Procedure	12
Behavioral	11
Biological\|Drug\|Other\|Procedure	8
Biological\|Drug\|Radiation	7
Drug\|Genetic	7
Dietary Supplement	6
Drug\|Other\|Radiation	6
Biological\|Drug\|Procedure	5
Combination Product	5
Device	5
Drug\|Genetic\|Other	3
Drug\|Other\|Procedure	3
Biological\|Device\|Drug	2
Biological\|Drug\|Genetic\|Other\|Procedure	2
Biological\|Procedure	2
Device\|Other	2
Dietary Supplement\|Other	2
Dietary Supplement\|placebo	2
Other\|Procedure	2
Behavioral\|Drug\|Other\|Procedure	1
Biological\|Device	1
Biological\|Device\|Drug\|Other\|Procedure	1
Biological\|Device\|Drug\|Procedure\|Radiation	1
Biological\|Device\|Drug\|Radiation	1
Biological\|Drug\|Genetic\|Other	1
Biological\|Drug\|Other\|Radiation	1
Biological\|Genetic\|Other	1
Biological\|Genetic\|Other\|Procedure	1
Biological\|Other\|Procedure	1
Biological\|placebo	1
Device\|Drug	1
Device\|Drug\|Other	1
Device\|Drug\|Other\|Procedure\|Radiation	1
Device\|Drug\|Procedure	1
Device\|Drug\|Procedure\|Radiation	1
Diagnostic Test\|Drug	1
Diagnostic Test\|Drug\|Genetic\|Procedure\|Radiation	1
Dietary Supplement\|Drug	1
Dietary Supplement\|Drug\|Other	1
Drug\|Genetic\|Procedure\|Radiation	1
Drug\|Other\|placebo\|Procedure	1
Drug\|placebo\|Procedure	1
Genetic	1
Genetic\|Other	1

Site_count	Study_Count
1	535
2	84
3	49
4	34
5	32
6	35
7	16
8	12
9	13
10	17
11	20
12	15
13	11
14	9
15	9
16	9
17	6
18	9
19	5
20	4
21	4
22	13
23	6
24	6
25	7
26	3
27	4
28	6
29	1
30	4
31	3
32	2
33	9
34	8
35	5
36	3
38	2
39	2
41	1
42	2
43	2
44	2
46	3
48	3
50	4
51	3
52	2
53	1
54	2
55	1
56	1
57	1
58	4
60	1
63	1
64	1
66	1
67	1
69	2
70	1
71	3
72	1
75	2
76	2
78	1
79	1
80	1
81	2
84	1
85	1
86	1
87	2
88	2
91	3
92	1
94	1
97	1
101	3
102	1
103	1
106	2
107	1
108	2
111	1
113	2
115	1
117	2
119	1
122	1
123	2
128	1
130	1
134	1
135	2
139	1
145	1
150	2
153	1
157	1
160	3
161	1
162	1
164	1
165	1
170	1
171	1
173	2
174	1
186	1
188	1
196	1
198	1
199	1
210	1
212	1
215	1
218	1
224	1
225	1
239	1
241	1
244	1
262	3
299	1
364	1
551	1
743	1
796	1
835	1
954	1

Count of Versions	Count of Studies
1	37
2	56
3	53
4	51
5	53
6	62
7	54
8	44
9	45
10	39
11	46
12	43
13	39
14	28
15	24
16	23
17	27
18	30
19	15
20	19
21	19
22	18
23	21
24	17
25	14
26	17
27	16
28	13
29	9
30	15
31	7
32	12
33	7
34	6
35	4
36	7
37	2
38	4
39	6
40	4
41	4
42	6
43	2
44	2
45	3
46	3
47	1
48	4
49	2
50	2
51	5
52	5
53	4
55	3
56	2
57	2
58	2
59	1
60	1
61	3
62	3
63	2
64	2
65	3
66	1
67	1
69	1
71	1
72	3
73	1
74	2
75	3
77	1
79	2
80	1
81	2
83	2
84	1
85	3
86	2
87	1
91	2
94	1
96	1
105	1
107	1
109	1
115	1
118	1
121	1
125	2
130	1
136	1
139	1
141	1
148	1
154	1
156	1
157	1
158	1
185	1
189	2
205	2
232	1
240	1
241	1
292	1
304	2
326	1
349	1
376	1
397	1
418	1
428	1
455	1
482	1
510	1
630	1
870	1
883	1

Site_count	Study_Count
1	80
2	6
3	6
4	2
5	5
6	1
8	1
9	2
10	2
11	1
13	2
14	2
15	2
16	1
17	2
18	1
19	2
21	1
25	1
31	1
33	1
34	1
35	1
39	1
41	2
47	1
51	1
55	1
59	1
66	1
71	1
84	1
112	1
135	1
137	1
165	1
183	1
200	1
244	1

Count of Versions	Count of Studies
1	14
2	19
3	17
4	12
5	12
6	6
7	4
8	2
9	7
10	6
11	4
13	2
14	4
15	2
17	2
20	1
22	1
23	1
25	1
27	2
30	1
45	1
47	1
66	1
71	1
73	1
78	2
83	1
84	1
118	1
122	1
124	1
126	1
164	1
185	1
239	1
297	1
341	1
364	1
391	1
460	1

Site_count	Study_Count
1	535
2	84
3	49
4	34
5	32
6	35
7	16
8	12
9	13
10	17
11	20
12	15
13	11
14	9
15	9
16	9
17	6
18	9
19	5
20	4
21	4
22	13
23	6
24	6
25	7
26	3
27	4
28	6
29	1
30	4
31	3
32	2
33	9
34	8
35	5
36	3
38	2
39	2
41	1
42	2
43	2
44	2
46	3
48	3
50	4
51	3
52	2
53	1
54	2
55	1
56	1
57	1
58	4
60	1
63	1
64	1
66	1
67	1
69	2
70	1
71	3
72	1
75	2
76	2
78	1
79	1
80	1
81	2
84	1
85	1
86	1
87	2
88	2
91	3
92	1
94	1
97	1
101	3
102	1
103	1
106	2
107	1
108	2
111	1
113	2
115	1
117	2
119	1
122	1
123	2
128	1
130	1
134	1
135	2
139	1
145	1
150	2
153	1
157	1
160	3
161	1
162	1
164	1
165	1
170	1
171	1
173	2
174	1
186	1
188	1
196	1
198	1
199	1
210	1
212	1
215	1
218	1
224	1
225	1
239	1
241	1
244	1
262	3
299	1
364	1
551	1
743	1
796	1
835	1
954	1

Count of Versions	Count of Studies
1	37
2	56
3	53
4	51
5	53
6	62
7	54
8	44
9	45
10	39
11	46
12	43
13	39
14	28
15	24
16	23
17	27
18	30
19	15
20	19
21	19
22	18
23	21
24	17
25	14
26	17
27	16
28	13
29	9
30	15
31	7
32	12
33	7
34	6
35	4
36	7
37	2
38	4
39	6
40	4
41	4
42	6
43	2
44	2
45	3
46	3
47	1
48	4
49	2
50	2
51	5
52	5
53	4
55	3
56	2
57	2
58	2
59	1
60	1
61	3
62	3
63	2
64	2
65	3
66	1
67	1
69	1
71	1
72	3
73	1
74	2
75	3
77	1
79	2
80	1
81	2
83	2
84	1
85	3
86	2
87	1
91	2
94	1
96	1
105	1
107	1
109	1
115	1
118	1
121	1
125	2
130	1
136	1
139	1
141	1
148	1
154	1
156	1
157	1
158	1
185	1
189	2
205	2
232	1
240	1
241	1
292	1
304	2
326	1
349	1
376	1
397	1
418	1
428	1
455	1
482	1
510	1
630	1
870	1
883	1

Site_count	Study_Count
1	80
2	6
3	6
4	2
5	5
6	1
8	1
9	2
10	2
11	1
13	2
14	2
15	2
16	1
17	2
18	1
19	2
21	1
25	1
31	1
33	1
34	1
35	1
39	1
41	2
47	1
51	1
55	1
59	1
66	1
71	1
84	1
112	1
135	1
137	1
165	1
183	1
200	1
244	1

Count of Versions	Count of Studies
1	14
2	19
3	17
4	12
5	12
6	6
7	4
8	2
9	7
10	6
11	4
13	2
14	4
15	2
17	2
20	1
22	1
23	1
25	1
27	2
30	1
45	1
47	1
66	1
71	1
73	1
78	2
83	1
84	1
118	1
122	1
124	1
126	1
164	1
185	1
239	1
297	1
341	1
364	1
391	1
460	1

leukemia, lymphoid

Study Counts

Studies over Time

Interventional Trials

Intervention Type

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Studies by Country

Sites per Study

Phase

Number of Arms

Number of Updates

Update History Change Type

Enrollment Metrics by Phase

Trial Group Type

Intervention Model

Primary Purpose

Observational Studies

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Observation Model

Time Perspective

Registries

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Registry Model

Time Perspective

Follow-up

Site_count	Study_Count
1	535
2	84
3	49
4	34
5	32
6	35
7	16
8	12
9	13
10	17
11	20
12	15
13	11
14	9
15	9
16	9
17	6
18	9
19	5
20	4
21	4
22	13
23	6
24	6
25	7
26	3
27	4
28	6
29	1
30	4
31	3
32	2
33	9
34	8
35	5
36	3
38	2
39	2
41	1
42	2
43	2
44	2
46	3
48	3
50	4
51	3
52	2
53	1
54	2
55	1
56	1
57	1
58	4
60	1
63	1
64	1
66	1
67	1
69	2
70	1
71	3
72	1
75	2
76	2
78	1
79	1
80	1
81	2
84	1
85	1
86	1
87	2
88	2
91	3
92	1
94	1
97	1
101	3
102	1
103	1
106	2
107	1
108	2
111	1
113	2
115	1
117	2
119	1
122	1
123	2
128	1
130	1
134	1
135	2
139	1
145	1
150	2
153	1
157	1
160	3
161	1
162	1
164	1
165	1
170	1
171	1
173	2
174	1
186	1
188	1
196	1
198	1
199	1
210	1
212	1
215	1
218	1
224	1
225	1
239	1
241	1
244	1
262	3
299	1
364	1
551	1
743	1
796	1
835	1
954	1

Count of Versions	Count of Studies
1	37
2	56
3	53
4	51
5	53
6	62
7	54
8	44
9	45
10	39
11	46
12	43
13	39
14	28
15	24
16	23
17	27
18	30
19	15
20	19
21	19
22	18
23	21
24	17
25	14
26	17
27	16
28	13
29	9
30	15
31	7
32	12
33	7
34	6
35	4
36	7
37	2
38	4
39	6
40	4
41	4
42	6
43	2
44	2
45	3
46	3
47	1
48	4
49	2
50	2
51	5
52	5
53	4
55	3
56	2
57	2
58	2
59	1
60	1
61	3
62	3
63	2
64	2
65	3
66	1
67	1
69	1
71	1
72	3
73	1
74	2
75	3
77	1
79	2
80	1
81	2
83	2
84	1
85	3
86	2
87	1
91	2
94	1
96	1
105	1
107	1
109	1
115	1
118	1
121	1
125	2
130	1
136	1
139	1
141	1
148	1
154	1
156	1
157	1
158	1
185	1
189	2
205	2
232	1
240	1
241	1
292	1
304	2
326	1
349	1
376	1
397	1
418	1
428	1
455	1
482	1
510	1
630	1
870	1
883	1

Site_count	Study_Count
1	80
2	6
3	6
4	2
5	5
6	1
8	1
9	2
10	2
11	1
13	2
14	2
15	2
16	1
17	2
18	1
19	2
21	1
25	1
31	1
33	1
34	1
35	1
39	1
41	2
47	1
51	1
55	1
59	1
66	1
71	1
84	1
112	1
135	1
137	1
165	1
183	1
200	1
244	1

Count of Versions	Count of Studies
1	14
2	19
3	17
4	12
5	12
6	6
7	4
8	2
9	7
10	6
11	4
13	2
14	4
15	2
17	2
20	1
22	1
23	1
25	1
27	2
30	1
45	1
47	1
66	1
71	1
73	1
78	2
83	1
84	1
118	1
122	1
124	1
126	1
164	1
185	1
239	1
297	1
341	1
364	1
391	1
460	1